Seminar

MWRI Work-in-Progress Seminar: Defining the Role of the Glucocorticoid Receptor in the Uterus and Understanding the Implications of Environmental Estrogen Exposure



Date
September 2, 2014
Time
12:00 PM - 1:00 PM
Speaker(s)
Shannon Whirledge, PhD
Research Fellow, Laboratory of Signal Transduction, National Institute of Environmental Health Science, Duke University, Durham, NC
Location
Magee-Womens Research Institute, Conf Center, 1st Floor
Contact
Admission
Registration is not required. Light lunch provided.
Physicians earn 1 CME credit
Description

The uterus is sensitive to stress-mediated actions of glucocorticoids and represents a direct target of the glucocorticoid receptor (GR). By generating a uterine-specific GR knockout mouse model, we are able to define those physiological events attributable to uterine expressed GR in vivo. The interplay of glucocorticoids and estradiol is mimicked by the environmental estrogen genistein. This results in aberrant uterine gene expression with unknown consequences.