Research Seminar

MWRI WIP "Turning out the lights on cancer cells: new therapeutics by attacking mitochondria and metabolism"

March 4, 2014
12:00 PM - 1:00 PM
Bennett Van Houten, PhD
Richard M. Cyert Professor of Molecular Oncology in the Department of Pharmacology and Chemical Biology
Magee-Womens Research Institute, 204 Craft Ave, Conf Center, 1st Floor
Earn 1 CME credit
LIght lunch provided; registration is not required

This lecture, after reviewing the Warburg effect, will present evidence for metabolic heterogeneity in tumor cells.

I will then present evidence that oxidative phosphorylation is an important source of energy for metastatic melanoma, and that a significant proportion of tumor cell’s energy budget comes from fatty acid beta-oxidation. Data will be presented that genetic or pharmacological inhibition of mitochondria fission causes G2/M arrest in tumor cells. Based on these results, I  will end with a new strategy for killing cisplatin resistant ovarian cancer cells.