Research Seminar

MWRI WIP "Expanding Nature's Toolbox of Biologically Relevant Compounds"

April 8, 2014
12:00 PM - 1:00 PM
Kay Brummond, PhD
Professor of Chemistry, University of Pittsburgh
Magee-Womens Research Institute, 204 Craft Ave, Conf Center, 1st Floor
Physicians earn 1 CME credit
Light lunch provided and registration is not required.

The primary focus of our research program is the development of new synthetic methods to expedite the preparation of, and to expand on Nature’s toolbox of biologically relevant compounds. Novel carbon-carbon bond forming strategies developed in our lab have led to the preparation of libraries of biologically relevant compounds and the deposition of over 500 compounds to the NIH molecular repository, on which thousands of bioactivity assays have been performed.  A highlight of Brummond’s contribution to this library program is the identification of an inhibitor to the ATM-ATR pathway, a small molecule hit that our collaborators are using as a chemical tool to decipher the mechanism in which these inhibitors sensitize p53-deficient cells to death without affecting the ATR kinase activity.