Research Seminar

MWRI WIP: Interchangeable α-kleisin subunits specify meiotic cohesin function in C. elegans

May 13, 2014
12:00 PM - 1:00 PM
Aaron Severson, PhD
Assistant Professor, Biological, Geological, and Environmental Sciences, Cleveland State University
Magee-Womens Research Institute Conf Center, 204 Craft Ave
Physician ear 1.0 CMEs
Light lunch provided and registration is not required.

Production of healthy gametes requires that genome copy number be reduced from two in diploid germline stem cell precursors to one in each haploid gamete (sperm or egg). Reducing ploidy requires precise regulation of the cohesin complexes that tether replicated sister chromatids and homologous chromosomes that have undergone crossover recombination. I will show that meiotic cohesin complexes in the nematode Caenorhabditis elegans differ in their kleisin subunit, and this single divergent subunit influences nearly every facet of meiotic cohesin function. The new paradigms for the function of cohesin in reducing genome copy number established through this work diverge from those previously elucidated in yeast but likely apply directly to plants and mammals, recently shown to utilize sets of meiotic kleisins similar to those we have identified in worms.