MWRI Work-in-Progress “Intratumor ploidy heterogeneity as a chemoresistance mechanism in triple-negative breast cancer”

October 13, 2015
12:30 PM
Rekha Gyanchandani, MS, PhD,
Postdoctoral Research Associate, Lee Lab, UPCI
Magee-Womens Research Institute, 204 Craft Ave, Conf Center 1st Floor
Physicians earn 1.0 CMEs.
Light lunch provided. Registration is not required.
The aim of this study is to elucidate the functional significance of polyploidy in triple-negative breast cancer (TNBC). We isolated and characterized the diploid and polyploid subpopulations occurring de novo or induced by chemotherapy in TNBC cell lines. Preliminary findings indicate that polyploid cells divide slower than the diploid cells and display resistance to mitotic inhibitor, docetaxel. In our future studies, we will examine these subpopulations for differences in their tumorigenic potential and role in tumor recurrence.