MWRI Work-in-Progress "Expression, activity and regulation of phosphorylating enzymes in Genital and Colorectal Tissues and Immune Cells"

October 14, 2014
12:00 PM - 12:30 PM
Minlu Hu
PhD Candidate, Rohan Lab, Magee-Womens Research Institute
Magee-Womens Research Institute, Conf Center, 1st Floor
Physicians earn 1.0 CME credits
Light lunch provided. Registration not required.

Phosphorylating enzymes responsible for activating NRTIs such as tenofovir are critical for their conversion to obtain intracellular antiviral activity, however there is limited data available regarding the expression of phosphorylating enzymes and their activity in the female genital tract. Data will be presented from a study which aims to compare the mRNA expression of phosphorylating enzymes in human female genital tract, colorectal tissue, and immune cells. Data will also be presented which examines the effect of contraceptives and inflammation on phosphorylating enzyme expression and TFV-DP formation in vaginal epithelial and immune cell lines.