Research Seminar

Manufactured Sperm and Oocytes from Stem Cells: Just how Promiscuous are Cells in Vitro? presented by Magee-Womens Research Institute's Work-in-Progress Seminar Series

September 17, 2013
12:00 PM - 1:00 PM
Gerald Schatten, PhD
Professor & Vice Chair, Dept of Ob/Gyn/RS, Dept of Cell Biology & Physiology, Univ of Pittsburgh; Director, Pittsburgh Development Center; Director, Division of Regenerative Medicine
Kelli Lazar
WIP Seminar Coordinator

The 2012 Nobel Prizes to John Gurdon and Shinya Yamanaka for their seminal work in nuclear transfer and induced pluripotency, coupled with the 2010 Nobel Prize to Bob Edwards for pioneering In Vitro Fertilization in humans, attests to the contemporary importance of stem cells and regenerative medicine for ART.  This lecture considers pluripotent stem cells, their differentiation into both oocytes and sperm in vitro, as well as their fidelity.  This differentiation of pluripotent stem cells into various progeny, including now oocytes and spermatids, is perplexing.  In vivo, Nature imposes strict fate constraintsYet in vitro, reprogrammed PSCs liberated from the body government freely differentiate into any phenotype (except placenta), violating even somatic vs. germ cell segregations – raising concerns regarding ‘Cellular Promiscuity.’