Research Seminar

MWRI WIP "The Role of Genomic Imprints in Mouse Placenta Development"



Date
March 18, 2014
Time
12:00 PM - 12:30 PM
Speaker(s)
Erik Koppes
Graduate Student Researcher, University of Pittsburgh, Magee-Womens Research Institute
Location
Magee-Womens Research Institute, 204 Craft Ave, Conf Center, 1st Floor
Admission
Physicians earn 1.0 CME credit
Light lunch provided and registration is not required.
Description

 

Genomic imprints are epigenetic marks inherited from parental genomes. In this study, the maternal effect Dnmt1o mouse model of loss of imprinting was used to investigate the collective role of genomic imprints in placenta development. Placentas from this model exhibit loss of imprinted DNA methylation with morphological defects in both labyrinth and spongiotrophoblast layers. I will also present preliminary results from a novel mouse model with a targeted deletion of the imprinted gene Klf14.