Research Seminar

MWRI Work-in-Progress Seminar: Isoform-specific requirement for PP1γ2 and GSK3α in mammalian sperm function and male fertility



Date
September 23, 2014
Time
12:00 PM - 1:00 PM
Speaker(s)
Srinivasan Vijayaraghavan, PhD
Professor, Department of Biological Sciences, Kent State University, Biomedical School, Northeastern Ohio Universities, College of Medicine
Location
Magee-Womens Research Institute, Conf Center, 1st Floor
Contact
Admission
Physicians earn 1 CME credit
Registration is not required. Light lunch provided.
Description

Identification of signaling mechanisms essential for male gamete function and fertility. In particular the roles of the serine/threonine protein phosphatase PP1g2 and the protein kinase GSK3a in epididymal sperm maturation,and sperm motility will be discussed.  The functions of the isoforms for each of these enzymes, PP1 and GSK3,  are  largely interchangeable in all mammalian tissues except in testis and sperm where they have  isoform-specific roles essential for male fertility.