Medicine Grand Rounds at UPMC Shadyside

Medicine Grand Rounds at UPMC Shadyside: “Manipulating the Tumor Microenvironment with Potent Immunotherapies of Cancer”



Date
August 24, 2017
Time
12:00 PM - 1:00 PM
Speaker(s)
Hassane M. Zarour, MD
Professor of Medicine, Immunology and Dermatology, University of Pittsburgh School of Medicine; Co-leader of the Melanoma Program, UPMC Hillman Cancer Center
Location
West Wing Auditorium, UPMC Shadyside
Category
UPMC Shadyside, Department of Medicine
Contact
Justine Rubino
Director, Operations, CCEHS


412-647-8261
rubinoje@upmc.edu
Description

Blocking the interaction between the programmed cell death (PD)-1 protein and one of its ligands, PD-L1, with blocking antibodies provides significant clinical benefits to cancer patients. To improve the clinical benefits of PD-1 blockade, we need to elaborate therapeutic strategies to counteract the tumor-intrinsic and tumor-extrinsic mechanisms of tumor-induced T cell dysfunction in the tumor microenvironment. Here, Dr. Zarour will present the data supporting the rationale for dual immune checkpoint blockade to improve the clinical benefits of PD-1 blockade in cancer.