Research Seminar

MWRI WIP Seminar Series: "Oncogenic properties of the tumor suppressor BRIP1"



Date
September 24, 2013
Time
12:00 PM - 12:30 PM
Speaker(s)
Daniel Hochbaum, PhD
Research Associate, Dept of Pharmacology, University of Pittsburgh
Location
Magee-Womens Research Institute, 204 Craft Ave, Conf Center, 1st Floor
Category
Magee-Womens Research Institute
Contact
Kelli Lazar
Program Coordinator


412-641-6052
klazar@mwri.magee.edu
Admission
Physicians earn 1 CME credit
Light lunch provided
Registration is not required
Description

BRCA1 is a hereditary tumor suppressor gene, that when mutated is associated with high risk for breast and ovarian cancer.  BRCA1 Interacting Protein 1 (BRIP1) is a binding partner of BRCA1 which is also a hereditary tumor suppressor gene.  In sporadic breast cancer, levels of BRCA1 are decreased, consistent with its tumor suppressor function.  In stark contrast, BRIP1 is amplified in 17% of breast tumors, in which 26% of these comprise the Luminal B subtype.  Knockdown of BRIP1 in cells harboring amplification slows down their growth.  In mechanistic studies aimed at understanding how BRIP1 promotes tumor growth we have identified BRIP1 as a component of the MEDIATOR transcriptional complex.  We are investigating if this novel function of BRIP1 contributes to its tumor promoting activity.