MWRI Work-in-Progress "Hops and Fears - Transposon Activity in the Mouse Germline"

October 28, 2014
12:00 PM - 1:00 PM
Alex Bortvin, MD, PhD
Adjunct Assistnat Professor, Dept of Embryology, Staff Member, Carnegie Institution of Washington
Magee-Womens Research Institute Conf Center 1st Floor
Physicians earn 1.0 CME credits
Light lunch provided. No registration required.

The last decade has seen a tremendous progress in our understanding of mechanisms of regulation of transposable elements in germ cells. Small RNA pathways are prominent players in this process along with DNA methylation and histone modifications. The talk will focus on results of studies of mouse Maelstrom, an evolutionarily conserved protein in the Piwi-interacting RNA (piRNA) pathway, that uncovered peculiar sex-specific relationships between mouse germ cells and their transposons that might be of significance for quantitative and qualitative aspects of gametogenesis in humans