Research Seminar

MWRI WIP: Uterine Leiomyomas and Infertility: Understanding the Role of Mediator Complex Subunit 12 (MED12) in Reproductive Tract Biology



Date
April 29, 2014
Time
12:00 PM - 12:30 PM
Speaker(s)
Priya Mittal
Graduate Student Researcher, University of Pittsburgh, Magee-Womens Research Institute
Location
Magee-Womens Research Institute, Conf Center, 1st Floor, 204 Craft Ave
Admission
Physicians earn 1.0 CME credits
Light lunch provided. Registration is not required.
Description

Uterine leiomyomas are the most frequently occurring gynecological tumors  in women. Recently, we  discovered  MED12 exon 2  mutations in  60- 70% of uterine leiomyomas. The most common of these mutations was a missense mutation at c.131 G>A in exon 2 of MED12 causing a glycine to aspartic amino acid change. To investigate the role of the mutation in tumor causation, we generated Med12 uterine specific conditional knockout mouse model, as well as Med12 uterine specific missense mutation model mirroring the human mutation. In this presentation, I will be discussing preliminary results from these two novel mouse models, suggesting that MED12 is critical for normal uterine function in mammals and that MED12 exon 2 mutations have a role in uterine leiomyoma causation.